This type of performance optimization is something useful to almost any site. From those that serve up thousands of pageviews a month to those that serve up millions of them.
Front end performance is, also, an area where most Drupal sites have noticeable room for improvement. In reviewing numerous sites built with Drupal there are few that don't have a lot of room for improvement.
Note: This session has been combined with High Performance Theming
Video at archive.org.